Scientist, Peptide Chemistry

The role

You will make and characterize peptide candidates for biological testing. You will execute the full synthesis workflow from resin loading through purification and quality control.

What you will do

• Execute end-to-end peptide synthesis workflows including resin loading, coupling, deprotection, cleavage, purification, and characterization.
• Run microwave-assisted solid-phase peptide synthesis and support routine synthesizer maintenance.
• Troubleshoot failed couplings, low crude purity, side products, cleavage issues, and instrument downtime.
• Purify and characterize candidates using analytical HPLC, prep HPLC, LC-MS, and related methods.
• Record identity, purity, yield, analytical traces, and batch-level quality-control data.
• Prepare compounds for in vitro and in vivo testing and maintain accurate experimental records.
• Share synthesis feasibility, purity, yield, stability, and analytical observations to inform design.

Required qualifications

• Hands-on chemistry experience
• Strong experimental discipline

Nice to have

• Experience with solid-phase peptide synthesis
• Experience with HPLC
• Experience with prep HPLC
• Experience with LC-MS

Benefits

• $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools
• Medical, dental, and vision coverage options
• Capable covers 100% of the base policy
• Access to HSA, FSA, and 401K plans
• Healthy vegetarian dinners provided daily

Before you apply

• Support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways
• In-person on site work trial in San Francisco

About the company

Capable Labs is a mission-driven team in San Francisco comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.