(Senior / Principal) Scientist, Therapeutic Discovery

The role

You will originate and lead new therapeutic programs from scientific concept through early validation. This involves identifying opportunities and defining targets, modalities, assays, and timelines.

What you will do

• Originate and lead therapeutic programs from concept through early validation.
• Critically evaluate literature, mechanisms, phenotypes, targets, and therapeutic ideas.
• Define program targets, mechanisms, modalities, assay strategies, biomarkers, model systems, and timelines.
• Select the right modality for each program.
• Execute alongside the scientific team through literature review, experimental design, and testing.
• Build capabilities around promising programs by identifying collaborators and partners.
• Own program progress and resource decisions.

Required qualifications

• A record of originating and advancing scientific or therapeutic programs.
• Strong scientific judgment.
• The ability to turn a promising mechanism or biological opportunity into an executable, falsifiable program.
• The breadth to evaluate targets, modalities, assays, biomarkers, model systems, translational paths, and program risks.
• A high-agency, precise, skeptical, and execution-oriented working style.
• The ability to lead interdisciplinary work.

Nice to have

• Created or helped create a drug candidate that advanced into clinical trials or reached the market.

Benefits

• $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools
• Medical, dental, and vision coverage options
• Capable covers 100% of the base medical policy
• Access to HSA, FSA, and 401K plans
• Healthy vegetarian dinners provided daily

Before you apply

• In-person on site work trial in San Francisco

About the company

Capable Labs is a mission-driven team in San Francisco comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.