(Senior / Principal) Scientist, Peptide Chemistry (Night Shift)

The role

You will lead peptide-chemistry execution on a dedicated night-shift schedule. This includes synthesis, purification, characterization, and biological handoffs.

What you will do

• Lead overnight peptide synthesis from route or sequence planning through reaction setup, solid- or solution-phase synthesis, cleavage, purification, characterization, and sample preparation.
• Run and optimize microwave-assisted solid-phase peptide synthesis.
• Resolve difficult overnight issues involving failed reactions, low conversion or purity, side products, solubility, cleavage or deprotection, purification, and instrument downtime.
• Purify and characterize compounds using analytical HPLC, prep HPLC, LC-MS, NMR, and related methods.
• Own identity, purity, yield, analytical traces, batch records, and sample readiness for in vitro and in vivo testing.
• Contribute chemistry insight on feasibility, SAR, stability, solubility, yield, and structure-property relationships.
• Provide disciplined morning handoffs covering results, failures, technical decisions, sample locations, risks, and follow-up actions.

Required qualifications

• Able and willing to work the designated night-shift schedule reliably.
• Five or more years of hands-on industry experience in peptide, medicinal, organic, or closely related chemistry.
• Strong synthetic-chemistry fundamentals, experimental judgment, and deep troubleshooting ability.
• Experience owning chemistry end to end, including design, synthesis, purification, characterization, quality control, and preparation for biological testing.
• A fast, rigorous, and safety-conscious working style with excellent experimental records.
• The ability to lead through technical judgment and create clean, useful handoffs across night and day teams.

Nice to have

• direct peptide experience is helpful

Benefits

• $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools
• Medical, dental, and vision coverage options, with Capable covering 100% of the base policy
• Access to HSA, FSA, and 401K plans
• Healthy vegetarian dinners with the team are provided daily

Before you apply

• In-person on site work trial in San Francisco

About the company

Capable Labs is a mission-driven team in San Francisco comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.