Scientist, Organic Chemistry

The role

You will synthesize, purify, and characterize compounds for small-molecule and adjacent therapeutic programs. You will own defined chemistry from route planning through material ready for biological testing.

What you will do

• Execute and optimize synthesis workflows, including route planning, reaction setup, workup, purification, characterization, and sample preparation for biological testing.
• Design, run, and troubleshoot organic reactions involving functional-group transformations, coupling chemistry, protecting-group strategies, late-stage diversification, and parallel synthesis.
• Use solution-phase and solid-phase synthesis workflows including cleavage, deprotection, crude analysis, purification, and final quality control.
• Resolve issues involving low conversion, poor selectivity, side products, decomposition, incomplete deprotection, solubility, purification, recovery, or instrument downtime.
• Purify and characterize compounds using analytical HPLC, prep HPLC, LC-MS, NMR, flash chromatography, SFC, and related methods.
• Prepare compounds for in vitro and in vivo studies and maintain clear experimental and batch-level quality-control records.
• Contribute chemistry insight on synthetic feasibility, SAR, purity, yield, stability, solubility, and structure-property relationships.

Required qualifications

• Hands-on synthetic chemistry experience
• Strong experimental discipline

Nice to have

• Experience with some of the listed synthetic or analytical methods

Benefits

• $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools
• Medical, dental, and vision coverage options
• Capable covers 100% of the base policy
• Access to HSA, FSA, and 401K plans
• Healthy vegetarian dinners provided daily

Before you apply

• Support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways
• In-person on site work trial in San Francisco

About the company

Capable Labs is a mission-driven team in San Francisco comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.