(Senior / Principal) Scientist, In Vivo Pharmacology

The role

You will lead the design, execution, and interpretation of mouse studies to evaluate therapeutic candidates. You will perform hands-on in-life work and use PK/PD, efficacy, and safety data to make candidate decisions.

What you will do

• Design, run, and interpret mouse studies evaluating therapeutic candidates across efficacy, pharmacology, and safety.
• Select appropriate dose, route, schedule, tissues, timepoints, endpoints, controls, and go/no-go criteria for each study.
• Perform and guide dosing by routes including IP, IV, SC, PO, intranasal, and other relevant methods.
• Perform or oversee in-life work, blood collection, necropsy, tissue collection, sample tracking, surgeries, and specialized procedures.
• Analyze PK/PD, efficacy, tolerability, biomarker, and tissue data to determine next steps.
• Design and execute EEG studies including surgery, electrode placement, monitoring, and electrophysiological-data processing.
• Coordinate with downstream molecular, histology, and biomarker workflows.

Required qualifications

• Substantial hands-on experience designing and running mouse studies in biotech, pharma, academia, or a closely related setting.
• Strong translational judgment to design studies that test tissue exposure, target engagement, pathway modulation, phenotype, and tolerability.
• Comfort with multi-route dosing, in-life execution, necropsy, tissue and blood collection, sample tracking, and coordination with downstream assays.
• The ability to interpret PK/PD and efficacy data and make disciplined next-study or candidate decisions.
• A fast, rigorous working style with explicit hypotheses, dose rationale, endpoints, controls, and go/no-go criteria.

Nice to have

• Prior experience with every route, procedure, or assay listed

Benefits

• $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools
• Medical, dental, and vision coverage options
• Capable covers 100% of the base policy
• Access to HSA, FSA, and 401K plans
• Healthy vegetarian dinners provided daily

Before you apply

• Support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways
• First phone screen
• Second phone screen
• In-person on site work trial in San Francisco

About the company

Capable Labs is a mission-driven team in San Francisco comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.