Scientist, Peptide Chemistry (Night Shift)

The role

You will run peptide-synthesis workflows on a dedicated night-shift schedule. You will own overnight execution, troubleshoot issues, maintain records, and provide handoffs to the day team.

What you will do

• Execute overnight peptide synthesis workflows, including resin loading, coupling and deprotection cycles, cleavage, purification, characterization, and sample preparation.
• Run microwave-assisted solid-phase peptide synthesis and support routine synthesizer maintenance during night-shift hours.
• Troubleshoot failed couplings, low crude purity, side products, cleavage issues, and instrument downtime.
• Purify and characterize candidates using analytical HPLC, prep HPLC, LC-MS, and related methods.
• Record identity, purity, yield, analytical traces, and batch-level quality-control data for morning handoff.
• Prepare compounds for in vitro and in vivo testing and maintain accurate experimental records.
• Provide clear handoffs covering completed work, failures, results, sample locations, risks, and follow-up actions.

Required qualifications

• Able and willing to work the designated night-shift schedule reliably and operate independently when needed.
• Hands-on chemistry or biochemistry laboratory experience and strong experimental discipline.
• Interest in owning the overnight synthesis workflow from reaction execution through purification, characterization, documentation, and sample handoff.
• A fast, rigorous, and safety-conscious approach to laboratory work.
• Proactive judgment when an instrument breaks, a synthesis fails, data look unusual, or a handoff needs clarification.

Nice to have

• Experience with solid-phase peptide synthesis, HPLC, prep HPLC, or LC-MS is valuable

Benefits

• $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools
• Medical, dental, and vision coverage options, with Capable covering 100% of the base policy
• Access to HSA, FSA, and 401K plans
• Healthy vegetarian dinners with the team are provided daily

Before you apply

• We support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways.
• In-person on site work trial in San Francisco

About the company

Capable Labs is a mission-driven team in San Francisco. The team includes members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.