Scientist, Organic Chemistry (Night Shift)

The role

You will run organic-chemistry workflows on a dedicated night-shift schedule. You will execute solution- and solid-phase chemistry and provide handoffs to the day team.

What you will do

• Execute overnight synthesis workflows, including route planning, reaction setup, workup, purification, characterization, and sample preparation.
• Run and troubleshoot organic reactions involving functional-group transformations, coupling chemistry, protecting-group strategies, late-stage diversification, and parallel synthesis.
• Use solution-phase and solid-phase methods including cleavage, deprotection, crude analysis, purification, and final quality control.
• Resolve overnight issues involving low conversion, poor selectivity, side products, decomposition, solubility, purification, recovery, and instrument downtime.
• Purify and characterize compounds using analytical HPLC, prep HPLC, LC-MS, NMR, flash chromatography, SFC, and related methods.
• Prepare compounds for in vitro and in vivo testing.
• Maintain accurate experimental and batch-level quality-control records.
• Provide clear morning handoffs covering completed work, results, failures, sample locations, risks, and follow-up actions.

Required qualifications

• Able and willing to work the designated night-shift schedule reliably and operate independently when needed.
• Hands-on synthetic chemistry experience and strong experimental discipline.
• Interest in owning overnight chemistry from reaction execution through purification, characterization, documentation, and sample handoff.
• A creative, fast, rigorous, and safety-conscious approach to laboratory problem-solving.
• Sound judgment when a reaction fails, an instrument is down, data look unusual, or the usual day-team contact is unavailable.
• The ability to maintain excellent records and create clean, useful handoffs across night and day teams.

Benefits

• $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools
• Medical, dental, and vision coverage options, with Capable covering 100% of the base policy
• Access to HSA, FSA, and 401K plans
• Healthy vegetarian dinners with the team provided daily

Before you apply

• Support visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways
• In-person on site work trial in San Francisco

About the company

Capable Labs is a mission-driven team in San Francisco. The team includes members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber.