Scientist - Ensemble Structural Informatics (CURRENTLY NOT ACCEPTING APPLICATIONS)

The role

This Scientist will lead the development of standards to allow the structural biology community to deposit, validate, search, and leverage dynamic structural information. The role involves architecting foundational infrastructure and building validation metrics for X-ray crystallography, cryo-EM, and related techniques.

What you will do

• Oversee development of ensemble-aware validation frameworks
• Identify and prioritize technical challenges from data representation to validation frameworks
• Guide the creation of data deposition, search, and retrieval tools
• Help coordinate with stakeholders to ensure interoperability and adoption
• Work with software developers, data engineers, and user experience designers to translate scientific requirements into technical solutions

Required qualifications

• Ph.D. in structural biology, biophysics, computational biology, or related field
• Demonstrated expertise in structural biology methods
• Deep understanding of structural heterogeneity and dynamics in biomolecular systems
• Experience with data standards, metadata frameworks, or scientific database development
• Strong collaborative skills and ability to build consensus across diverse scientific communities

Nice to have

• Experience with PDB, EMDB, BMRB, or other structural biology databases
• Knowledge of validation methods for experimental and computational structural data
• Familiarity with machine learning workflows and ML-ready data formats
• Background in model uncertainty quantification or ensemble refinement methods
• Understanding of software development practices and data engineering principles
• Track record of working at the interface of methods development and infrastructure

About the company

Prism is a program within Radial, the basic life sciences division of the Astera Institute. They are building open infrastructure for studying protein dynamics directly from experimental data.