Insitro
Associate Scientist III, Cardiac Modeling
South San Francisco, CA. Posted 2 months ago
The role
You will support the development and application of iPSC-derived cardiomyocyte models to study cardiovascular disease. This involves designing experiments, optimizing differentiation workflows, and developing functional assays to connect cellular phenotypes to disease mechanisms.
What you will do
- Support generation and maintenance of iPSC lines and differentiation into cardiomyocytes in 2D format
- Implement quality control points for production scalability
- Assist in building isogenic iPSC-CM disease models using patient and CRISPR-edited lines
- Characterize cellular models to study cardiovascular pathophysiology
- Support development and optimization of functional assays like contractility, electrophysiology, and calcium handling
- Write and review technical procedures and SOPs
- Present results in team meetings
- Maintain laboratory notebook with scientific rigor
- Contribute to target identification and validation efforts
Required qualifications
- Bachelor's or master's degree in biology, biochemistry, or related discipline
- At least 2 years of relevant experience in the biotech/biopharma industry
- Deep hands-on experience in iPSC culture, cardiac directed differentiation and iPSC-CM model characterization in 2D (monolayer) format
- Experience developing genetic iPSC-CM disease models including patient-derived lines and CRISPR-edited isogenic pairs
- Experience with functional assays such as contractility, calcium, electrophysiology, imaging, and stress responses
- Hands-on expertise in molecular assays such as PCR, RT-qPCR, Western Blot and immunofluorescence
- Track record of executing rigorous experiments and communicating findings in publications, presentations or internal reports
Nice to have
- Prior experience in 3D/engineered heart tissue platforms or organoids
- Background in cardiomyocyte biology and/or cardiovascular disease
- Prior exposure and experience working with high-throughput platforms and/or automated systems
Benefits
- 401(k) plan with employer matching
- Medical, dental, and vision coverage
- Mental health and well-being support
- Open, flexible vacation policy
- Paid parental leave of at least 16 weeks for birth parents and 10 weeks for new parents
- Quarterly budget for books and online courses
- New hire stipend for home office setup
- Monthly cell phone & internet stipend
- Access to free onsite baristas and daily lunch
- Access to a free commuter bus network
About the company
insitro is a physical AI company and drug discovery company using machine learning and data at scale to decode biology for transformative medicines. The company uses a Virtual Human platform and a TherML platform to identify genetic intervention points and translate them into therapeutics.