Research Scientist I/II, Immunology

The role

This person will design and execute in vitro and ex vivo studies to support small-molecule drug discovery programs. They will work with biology, medicinal chemistry, DMPK, in vivo pharmacology, computational biology, machine learning, and compound management groups.

What you will do

• Design, develop, optimize, troubleshoot, and execute assays using immune cells and tissues.
• Run recurring compound-profiling assays to support medicinal chemistry cycles.
• Apply quantitative pharmacology to analyze concentration-response relationships and assay performance.
• Maintain accurate electronic laboratory records, protocols, and data packages.
• Communicate results and technical risks at biology and project-team meetings.
• Support in vivo immunology studies through experimental planning, sample processing, and ex vivo analyses.
• Support assay transfer and external studies with CROs or collaborators.
• Contribute to laboratory operations, reagent and instrument qualification, and method documentation.

Required qualifications

• PhD in immunology or a related field, or another biological discipline with immunology-focused postdoctoral training, plus 0–4 years of relevant experience; or MS with 7+ years / BS with 9+ years of r
• Strong knowledge of innate and/or adaptive immunology, immune-cell signaling, and disease-relevant mechanisms.
• Strong hands-on experience designing and executing in vitro and ex vivo immunology studies using primary human and/or animal immune cells, whole blood, or tissue-based systems.
• Proficiency in multiparameter flow cytometry, cytokine/chemokine assays, and complementary functional or molecular readouts.
• Ability to develop, troubleshoot, and document robust cell-based assay cascades.
• Experience supporting small-molecule discovery through compound screening or profiling.
• Working knowledge of in vivo immunology and pharmacology, including model selection, dosing, endpoints, tissue collection, PK/PD, and pharmacodynamic biomarkers.
• Demonstrated scientific rigor, sound experimental judgment, strong organization and communication.

Nice to have

• experience transferring assays to CROs or automated/HTS platforms
• exposure to hit identification, hit-to-lead, or lead optimization
• direct hands-on experience with in vivo immunology and pharmacology

Benefits

• company-paid medical coverage
• flexible spending accounts
• voluntary life insurance
• 401(k) matching
• flexible time off
• community gym
• dining

About the company

Iambic Therapeutics (Nasdaq: IAM) is a technology and clinical-stage life sciences company headquartered in San Diego. The company utilizes molecular superintelligence to address the totality of drug discovery and development.