Research Scientist I/II, Bioanalytical Sciences & Assay Development

The role

This scientist will develop and implement mass spectrometry-based assays and bioanalytical workflows. They will support Hit Identification, ADME/DMPK characterization, and physicochemical property assessment.

What you will do

• Develop and implement MS-based assays and screening workflows for HitID, including ASMS and other MS-based approaches.
• Develop fit-for-purpose bioanalytical and biochemical assays supporting screening, hit confirmation, and compound characterization.
• Develop and execute in vitro ADME/DMPK assays, including metabolic stability, permeability, protein binding, and related endpoints.
• Develop physicochemical property assays, including solubility, logD/lipophilicity, ePSA, and related measurements.
• Develop and optimize LC-MS/MS bioanalytical methods and troubleshoot assay performance, sensitivity, selectivity, matrix effects, and reproducibility.
• Develop automated and high-throughput assay workflows to improve capacity, turnaround time, and data quality.
• Support operation and troubleshooting of MS and LC/MS instrumentation and associated laboratory automation.
• Generate high-quality experimental datasets that support AI/ML-driven compound design and optimization.
• Collaborate with biology, screening/HitID, medicinal chemistry, DMPK, and computational/AI teams.
• Evaluate new assay technologies, MS methodologies, automation solutions, and data workflows.

Required qualifications

• Ph.D. in Bioanalytical Chemistry, Mass Spectrometry, Chemical Biology, Drug Metabolism/Pharmacokinetics, Pharmaceutical Sciences, Biochemistry, or a related discipline, with approximately 0–5 years of
• Strong foundation in mass spectrometry, bioanalytical science, and assay development.
• Demonstrated experience developing, optimizing, and troubleshooting bioanalytical, biochemical, or screening assays.
• Strong understanding of quantitative assay design, experimental controls, data quality, and troubleshooting.
• Strong scientific problem-solving and collaboration skills.

Nice to have

• Experience with MS-based screening or HitID approaches, including ASMS or related technologies
• Experience with in vitro ADME/DMPK and/or physicochemical property assays such as solubility, logD, and ePSA
• Experience with SCIEX, Agilent, Thermo, or comparable MS/LC-MS platforms
• Experience with laboratory automation, high-throughput screening/experimentation, or automated data processing

Benefits

• Company-paid medical coverage
• Flexible spending accounts
• Voluntary life insurance
• 401(k) matching
• Flexible time off
• Community gym
• Dining

About the company

Iambic Therapeutics (Nasdaq: IAM) is a technology and clinical-stage life sciences company headquartered in San Diego. The company utilizes molecular superintelligence by integrating proprietary AI with automated, scalable chemistry and biology experimentation.