Senior Associate Scientist I/II, Purification Sciences

The role

This individual will perform chromatography-based purification to support small-molecule drug discovery. They will focus on preparative LC and preparative SFC to support medicinal chemistry and high-throughput chemistry efforts.

What you will do

• Perform routine and moderately complex small-molecule purification using preparative LC and SFC.
• Develop and optimize purification methods.
• Operate prep LC, prep SFC, analytical LC, and LC/MS systems.
• Perform analytical QC of purified compounds.
• Perform routine instrument maintenance and troubleshoot chromatography, fluidics, hardware, and software issues.
• Monitor instrument performance to maintain laboratory operations.
• Support high-throughput and automated purification workflows.
• Work with medicinal chemists to prioritize samples and deliver purified compounds.
• Support evaluation and implementation of new purification methods, columns, and instrumentation.
• Maintain accurate experimental and instrument documentation.

Required qualifications

• B.S. or M.S. in Chemistry, Pharmaceutical Sciences, Chemical Engineering, or a related discipline with 3+ years of experience
• Relevant hands-on laboratory experience in chromatography and small-molecule purification
• Working knowledge of chromatographic separation principles and method optimization
• Strong attention to detail
• Problem-solving skills
• Ability to work effectively in a fast-paced, collaborative research environment

Nice to have

• Experience with preparative LC and/or preparative SFC
• SFC experience
• Experience operating and troubleshooting chromatography instrumentation
• Experience with LC/MS-based characterization and purity assessment
• Experience with automated or high-throughput laboratory workflows
• Experience with Agilent, Shimadzu, SCIEX, or comparable platforms

Benefits

• Company-paid medical coverage
• Flexible spending accounts
• Voluntary life insurance
• 401(k) matching
• Flexible time off
• Community gym
• Dining

About the company

Iambic Therapeutics is a technology and clinical-stage life sciences company headquartered in San Diego. The company utilizes molecular superintelligence to address the totality of drug discovery and development.