Research Scientist I / II – High Throughput Chemistry

The role

The Research Scientist will design, optimize, and execute high-throughput experiments to drive compound library campaigns. This role uses organic synthesis, catalysis, and reaction development to support discovery programs using the HTE platform.

What you will do

• Design and execute parallel synthetic methods to generate large, high-quality compound libraries.
• Identify, develop, and optimize novel synthetic methodologies with a focus on automation compatibility and HTE scalability.
• Apply newly developed synthetic routes from traditional bench-scale chemistry to robust, high-throughput, and automated processes.
• Oversee the operation, maintenance, and continuous advancement of our chemistry toolkit and automated synthesis equipment.
• Analyze research outcomes and library compound data and communicate results to cross-functional project teams.
• Ensure all laboratory work is conducted in accordance with established safety protocols and ELN data recording practices.
• Function as a core member of an interdisciplinary scientific team.
• Identify bottlenecks, troubleshoot automated processes, and develop solutions.

Required qualifications

• Ph.D. in Organic Chemistry with 0-5 years of industry experience or MS in Organic Chemistry with a minimum of 8 years of industry experience.
• Strong command of modern organic synthetic methods.
• Direct hands-on experience with High Throughput Chemistry and/or Parallel Synthesis.
• Experience with laboratory automation, liquid handling robotics, and automated analytical and purification systems.
• Ability to thrive in a fast-paced, highly collaborative, and dynamic research environment.
• Excellent written and verbal communication skills.
• Proven ability to thrive in a fast-paced, high-volume environment where priorities and synthetic targets may shift rapidly based on biological data.

Nice to have

• Experience with Direct-to-Biology (D2B) strategies for drug discovery.
• Familiarity with the principles of medicinal chemistry.
• Prior experience mentoring interns or junior colleagues.

Benefits

• Company-paid medical coverage
• Flexible spending accounts
• Voluntary life insurance
• 401(k) matching
• Flexible time off
• Community gym
• Dining

About the company

Iambic Therapeutics (Nasdaq: IAM) is a technology and clinical-stage life sciences company headquartered in San Diego. The company utilizes molecular superintelligence by integrating proprietary AI with automated, scalable chemistry and biology experimentation.