Principal Scientist, Medicinal Chemistry

The role

The Principal Scientist will devise strategies to identify and optimize lead molecules for potency, selectivity, and ADME properties. This role involves working with multidisciplinary teams including biology, pharmacology, and AI/ML to develop predictive models and leverage automated synthesis.

What you will do

• Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties
• Execute high quality ideas using modern organic chemistry transformations and synthetic methods
• Work closely with molecular and cellular biology, pharmacology, computational chemistry, and ADME
• Influence the prospective use of computational methods and leverage automated synthesis and high-throughput experimentation
• Work closely with AI/ML teams to develop and implement predictive models
• Communicate project updates to the broader team and key stakeholders
• Work as a member of the Chemistry research group

Required qualifications

• BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry
• Experience in small molecule drug discovery in a biotechnology or pharmaceutical setting
• B.S. with 15+ years’ experience, M.S. with 12+ years’ experience or Ph.D. with 8+ years’ experience
• Proven track record of success in advancing programs from leads to advanced candidates
• Extensive experience in lead compound optimization for potency, selectivity, ADME and PK
• Expert in modern synthetic organic chemistry approaches and principles demonstrated through publications in journals and patents
• Ability to integrate multiple R&D disciplines into a successful strategic project plan
• Experience working with computational chemists as part of project team in design of drug targets
• Strong interpersonal, communication, time management, and leadership skills
• Creative problem solving and management of relationships with several stakeholders

Benefits

• Company-paid medical coverage
• Flexible spending accounts
• Voluntary life insurance
• 401(k) matching
• Flexible time off
• Community gym
• Dining

About the company

Iambic Therapeutics is a technology and clinical-stage life sciences company headquartered in San Diego. The company utilizes molecular superintelligence by integrating proprietary AI with automated, scalable chemistry and biology experimentation.