Research Scientist I/II, Purification Sciences

The role

This scientist will develop and advance small-molecule purification and high-throughput analytical capabilities. They will provide expertise in preparative SFC and LC purification and high-throughput compound QC to support medicinal chemistry and high-throughput experimentation platforms.

What you will do

• Develop and execute small-molecule purification strategies using preparative SFC and LC.
• Solve challenging separations through optimization of stationary/mobile phases, selectivity, gradients, sample loading, scale-up, and fraction collection.
• Develop and support high-throughput compound QC workflows using LC/MS and related analytical techniques.
• Collaborate with medicinal chemistry and HTE teams to establish purification and QC strategies.
• Serve as a technical resource for SFC/LC purification, analytical QC, and instrument troubleshooting.
• Provide hands-on support for SFC, LC, and LC/MS platforms, including maintenance and vendor coordination.
• Develop and improve automated and high-throughput purification and QC workflows.
• Evaluate and implement new chromatography, analytical, automation, and informatics technologies.

Required qualifications

• Ph.D. in Chemistry, Pharmaceutical Sciences, Chemical Engineering, or a related discipline with 0-5 years of relevant experience; or a MS with 7+ years / BS with 9+ years of relevant experience.
• Strong hands-on expertise in small-molecule chromatographic purification and method development.
• Demonstrated expertise in preparative SFC, including method development, optimization, and troubleshooting.
• Strong understanding of chromatographic separation science and ability to independently solve complex purification problems.
• Strong instrument troubleshooting skills, including experience diagnosing chromatography, fluidics, hardware, and software issues.
• Strong understanding of medicinal chemistry and small-molecule drug discovery.
• Excellent scientific problem-solving, communication, and collaboration skills.

Nice to have

• Preparative LC experience is strongly preferred.
• Experience with high-throughput LC/MS analysis and compound QC, including purity and identity assessment, is strongly preferred.
• Experience with automation, high-throughput workflows, and informatics/data-management systems is highly desirable.
• Experience with Agilent, Shimadzu, or comparable analytical and purification platforms is a plus.

Benefits

• Company-paid medical coverage
• Flexible spending accounts
• Voluntary life insurance
• 401(k) matching
• Flexible time off
• Community gym
• Dining

About the company

Iambic Therapeutics (Nasdaq: IAM) is a technology and clinical-stage life sciences company headquartered in San Diego. The company utilizes molecular superintelligence to address the totality of drug discovery and development.