Machine Learning Scientist – Clinical Prediction

The role

You will design and implement clinical fine-tuning of Enchant, a multimodal transformer model. This role involves identifying, curating, and evaluating datasets to support prediction of clinical endpoints and deploying models for therapeutic decisions.

What you will do

• Fine-tune large-scale multimodal transformer models for clinical and biomedical applications
• Identify, characterize, and utilize datasets for PK, PD, toxicity, adverse events, and clinical trial outcomes
• Develop and apply rigorous experimental approaches to account for potential leakage
• Design and maintain benchmarking and evaluation frameworks
• Build models with appropriate calibration, uncertainty quantification, and clinically meaningful evaluation metrics
• Collaborate with ML and software engineering colleagues to deploy and operationalize models
• Partner with clinical scientists and pharmacologists to ensure model development meets drug discovery needs
• Communicate results to internal teams, external partners, and at conferences
• Generate high-quality research and engineering code

Required qualifications

• MS in chemistry, bio/chemical engineering, or a computational STEM field with 3+ years of relevant industry or research experience, or PhD or equivalent industry experience
• Strong Python experience, including implementing and fine-tuning deep learning models
• Demonstrated experience in clinical science or working with clinical datasets
• Excellent Data Science skills
• Enough independence to own a workstream from data ingestion through evaluation
• Strong engineering habits: reproducible experimentation, appropriate control strategy, clean code, testing
• Comfort working with modern ML infrastructure (e.g., Docker, CUDA, Kubernetes, experiment tracking such as Weights & Biases)

Nice to have

• Experience building and deploying clinically relevant prediction models
• Familiarity with ClinicalTrials.gov/AACT data
• Experience with MedDRA, pharmacovigilance, or adverse event data
• Direct exposure to multi-task learning
• Hands-on experience with agentic data extraction
• HPC or large-scale computing experience

Benefits

• Company-paid medical coverage
• Flexible spending accounts
• Voluntary life insurance
• 401(k) matching
• Flexible time off
• State-of-the art facility in San Diego
• Community gym
• Dining

About the company

Iambic Therapeutics is a technology and clinical-stage life sciences company headquartered in San Diego. The company utilizes molecular superintelligence to address the totality of drug discovery and development.