AI Biologist - Structural Biology

The role

You will act as a scientific authority to test if AI agents can reason like expert structural biologists. You will build benchmark tasks, curate datasets, and develop analysis pipelines to evaluate agent outputs across molecular systems.

What you will do

• Define expert reasoning for structural questions and write gold-standard answers
• Design realistic scenarios across the structural workflow
• Curate datasets across modalities including X-ray, cryo-EM, and NMR
• Build analysis pipelines in Python
• Partner with software engineers to turn judgment into new workflows
• Test whether agents distinguish real structure from artifact
• Adjudicate ambiguous cases in maps or measurements
• Test whether agents choose the right representation and comparison
• Interrogate agent reasoning step by step
• Pinpoint where agents go wrong and score agent confidence

Required qualifications

• PhD in structural biology, biophysics, biochemistry, or a related field
• Hands-on structural experience building and validating models
• Deep expertise in at least one area (X-ray crystallography, cryo-EM, NMR/solution methods, or computational structural biology)
• Working fluency across the other structural areas
• Coding for structural data in Python (gemmi, Biopython/biotite, numpy)
• Daily use of Claude, Cursor, or similar agents
• Ability to calibrate confidence and communicate uncertainty

Nice to have

• structural virology or antibody–antigen structural work (viral glycoproteins, epitope mapping, structural interpretation of escape)
• RNA structural biology
• protein–RNA interaction analysis

Benefits

• Health, dental, vision: 100% covered for you, 50% for dependents
• 401(k) (no match)
• PTO: 12 days to start
• Catered lunch and dinner (onsite)
• Unlimited snacks (onsite)
• Company outings and team off-sites

Before you apply

• If your profile matches, you will receive a take-home project
• Background check once you accept

About the company

Latch builds rigorous scientific benchmarks for AI agents across biology. They work with frontier labs and pharma to measure if agents can handle real biological workflows.