AI Biologist - Biologics Development

The role

You will act as the scientific authority on ground truth to test if AI agents can reason like expert biologics development scientists. You will build tasks and datasets, set hard calls for agent performance, and judge agent reasoning.

What you will do

• Turn real development workflows into file-based tasks with structured outputs and deterministic grading
• Write gold-standard answers from raw data
• Curate data fixtures
• Partner with software engineers to turn judgment into new workflows
• Test whether agents can tell a real liability from an artifact
• Test whether agents match effector function and affinity to the mechanism
• Test whether agents distinguish linear from target-mediated clearance
• Interrogate agent reasoning step by step
• Pinpoint where agents go wrong
• Score agent confidence

Required qualifications

• PhD in protein engineering, biochemistry, analytical chemistry, pharmacology, or a related field
• Hands-on analysis of antibody development data
• Deep expertise in at least one area (analytical/CMC characterization, large-molecule DMPK, protein engineering and developability, or non-clinical safety) and working fluency across the others
• Command of how readouts map to critical quality attributes, PK and effector properties, and release or comparability decisions
• Python or R for data analysis, including parsing chromatograms and electropherograms, kinetic fitting, or PK modeling
• Daily use of Claude, Cursor, or similar agents
• Confidence to overrule an AI agent when the evidence demands it
• Ability to calibrate confidence and communicate uncertainty

Nice to have

• antibody format and Fc engineering experience (IgG subclasses, YTE/LS, effector-silencing, bispecific architectures)
• familiarity with MAM, ICH Q6B/Q5E, FDA immunogenicity guidance, IMGT, SAbDab, and IEDB

Benefits

• Health, dental, vision: 100% covered for you, 50% for dependents
• 401(k) (no match)
• PTO: 12 days to start, more as you're promoted
• Catered lunch and dinner and unlimited snacks (onsite)
• Company outings most months, team off-sites, and a community

Before you apply

• If your profile matches, we’ll send you a take-home project
• Take-home project (HackerRank)
• Technical interview with a Member of Technical Staff (pod lead)
• Culture interview with our C-suite
• Background check, once you accept

About the company

Latch builds rigorous scientific benchmarks for AI agents across biology. They work with frontier labs and pharma to measure whether agents can handle real biological workflows.