Scientist, Biophysical Characterization (SPR/BLI)

The role

You will own biophysical characterization on the Medra Physical AI platform. You will develop, validate, and scale label-free binding assays like SPR and BLI into autonomous, high-throughput workflows.

What you will do

• Develop, validate, and run SPR and BLI assays across various formats
• Design assay strategies for antibody and alternative binder characterization
• Build new biophysical capabilities end-to-end including instrument qualification and SOP writing
• Partner with roboticists and software engineers to translate workflows into autonomous protocols
• Develop data analysis and QC frameworks for kinetics fitting and binning heatmaps
• Integrate biophysical data with orthogonal characterization
• Work with customers to scope characterization campaigns and translate scientific questions
• Maintain experimental records in electronic lab notebooks

Required qualifications

• Ph.D. in biochemistry, biophysics, structural biology, or a related discipline with 2+ years of industry experience, or a B.S./M.S. with 6+ years of deep, hands-on industry experience
• Deep hands-on expertise with SPR and/or BLI
• Strong command of binding kinetics theory
• Demonstrated experience developing and qualifying biophysical assays from scratch
• Working understanding of antibody structure, function, and the therapeutic antibody discovery and developability process
• Strong documentation habits
• Attention to detail
• Ability to drive multiple workstreams in parallel

Nice to have

• Hands-on experience with high-throughput SPR platforms (e.g., Carterra LSA) and array-based epitope binning
• Experience with alternative binder formats — VHHs, bispecifics, Fc-fusions, or non-Ig scaffolds
• Hands-on experience with lab automation and liquid handling platforms (e.g., Lynx, Tempest, KingFisher)
• Experience developing developability assay panels (nanoDSF/DLS, HPLC-SEC/HIC, AC-SINS) and integrating multi-instrument datasets
• Experience building analysis pipelines or scripting for high-throughput kinetics data (Python/R)
• Track record of developing and qualifying new assays or platforms from scratch

Benefits

• Significant equity ownership
• 401k
• Medical insurance
• Dental insurance
• Unlimited PTO
• Weekday lunches and dinners
• Relocation benefits

About the company

Medra uses AI, robotics, and biology to accelerate life science research to eradicate disease. They are building a Physical AI Scientist platform.