(Principal) Senior Scientist, Pharmacology

The role

This person will lead molecular biology strategy and execution for studies characterizing RNA therapeutic candidates. They will own studies from experimental design through data interpretation and integrate molecular readouts with in vivo and program data.

What you will do

• Design and lead quantitative molecular biology studies for PK, PD, biodistribution, target engagement, and gene expression.
• Develop, optimize, qualify, and oversee workflows for RNA and DNA extraction, cDNA synthesis, RT-qPCR, qPCR, ddPCR, and related assays.
• Establish sample-processing workflows across cells, tissues, and biofluids.
• Translate program questions into study strategies with controls, acceptance criteria, and timelines.
• Analyze and integrate complex datasets including molecular, exposure, and efficacy readouts.
• Lead troubleshooting and root-cause investigations for assay and instrument performance.
• Establish and maintain SOPs, assay qualification summaries, and training materials.
• Ensure accurate, real-time documentation in the electronic lab notebook.
• Coordinate cross-functionally to align sample generation and analysis with program timelines.
• Present data to guide experimental plans and program decisions.

Required qualifications

• PhD in Molecular Biology, Biochemistry, Genetics, Pharmacology, Bioengineering, or a related field, or an equivalent combination of advanced training and relevant industry experience
• Deep hands-on experience with quantitative PCR methods and molecular assay development, including work with complex tissue or biofluid samples
• Demonstrated ability to design pharmacology studies, interpret pharmacokinetic and pharmacodynamic readouts, and integrate molecular results with cross-functional datasets
• Experience with RNA therapeutic development including preclinical pharmacology data preparation and presentation for scientific and regulatory interactions
• Ability to work on site in our laboratory at Research Park at Marina Village in Alameda, California

About the company

Nosis Bio is a well-funded biotech startup focused on cell-specific delivery of RNA therapeutics. They combine expertise in receptor biology, generative AI, and high-throughput in vivo data generation to accelerate RNA therapeutic development.