Scientist II

The role

This Scientist II will support biomarker measurements and clinical pharmacology deliverables by developing novel bioanalytical methods. The role involves executing gene expression assays, molecular biology, ligand binding assays, cell culture, and histology workflows.

What you will do

• Develop and execute Immunogenicity, PK/PD, and biomarker assays for preclinical and clinical use
• Execute molecular biology experiments including nucleic acid, ddPCR, plasmid and vector construction, and molecular cloning
• Execute ligand binding and protein assays such as MSD and ELISA
• Perform cell culture activities and sample preparation
• Review and interpret bioanalytical datasets for quality, trends, and consistency
• Summarize findings for study teams and contribute to data summaries
• Perform histology sample preparation and IHC/ISH experimental execution
• Provide effective data summary and presentation to internal teams
• Manage assays performed externally at CROs
• Support biobank, safety and lab maintenance activities

Required qualifications

• Degree in Immunology, Bioengineering, Molecular Biology, Cell Biology, Pharmacology, Biochemistry or related field
• PhD in a relevant scientific discipline with 5+ years of industry experience; OR
• Master's degree with 7- 8+ years of industry or related experience; OR
• Bachelor's degree with 9-11+ years of industry or related experience
• AAV Vector experience
• Cell culture, sample preparation
• Experience with PCR, qPCR, and droplet digital PCR; RNA-seq; and tissue culture of primary cells and established cell lines
• Bioanalytical and/or biomarker assay development experience
• Working knowledge of clinical pharmacology concepts (PK/PD, exposure metrics, dose selection, exposure–response)
• Experience translating study objectives into bioanalytical strategy
• Molecular biology: qPCR, ddPCR, plasmid and vector construction, molecular cloning, and other nucleic acid manipulations
• Ligand binding assays, cell-based assays

About the company

4DMT is a leading late-stage biotechnology company advancing durable and disease-targeted therapeutics. The company's lead product candidate 4D-150 is designed to provide multi-year sustained delivery of anti-VEGF biologics.