AI Scientist, BioMedical AI

The role

You will develop and apply foundation models to large-scale perturb-seq and single-cell datasets. The goal is to uncover new biological mechanisms and therapeutic opportunities, working closely with experimental biologists.

What you will do

• Design, train and refine foundation models for perturb-seq and other single-cell datasets.
• Build pipelines for preprocessing, normalization and integration of large-scale single-cell and perturbation data.
• Apply ML/AI approaches to model cellular responses to perturbations and identify causal biological insights.
• Collaborate with experimental biologists to align computational methods with experimental design and discovery goals.
• Develop multimodal integration approaches across transcriptomic, epigenomic and proteomic single-cell readouts.
• Publish methods and results in top scientific journals and present at conferences.

Required qualifications

• PhD or equivalent in Computational Biology, Computer Science, Bioinformatics or a related discipline.
• Strong expertise in single-cell data analysis, particularly perturb-seq.
• Hands-on experience with foundation models or large-scale self-supervised learning (e.g., transformers, variational autoencoders).
• Strong coding skills in Python, ML frameworks (PyTorch/TensorFlow) and single-cell analysis tools (Scanpy, Seurat).
• Experience developing scalable ML methods for large biological datasets.

Nice to have

• Background in causal inference, generative models or representation learning for biological systems.
• Familiarity with multi-omics integration and cross-modal foundation models.
• Track record of impactful publications in computational biology, machine learning or related fields.

Benefits

• Competitive compensation and benefits package.
• Base salary, bonus and equity.
• Open, flexible and friendly work environment.
• Platform to develop long-term careers.
• Summary of Benefits available to all applicants.

Before you apply

• Agency resumes are not accepted; do not forward resumes to the jobs alias or employees.

About the company

Xaira Therapeutics is an AI-focused biotech startup using generative AI to design protein and antibody therapeutics and foundation models for biology and disease. It is headquartered in the San Francisco Bay Area, Seattle and London.