Scientist I/II, Functional Genomics

The role

Lead the development of organoid model systems for high-throughput functional genomics and CRISPR screening. Work across organoid biology, data science, AI/ML and translational research, balancing strategic leadership with hands-on technical work.

What you will do

• Develop, implement and scale organoid-based model systems to support high-throughput CRISPR screening.
• Establish and optimize protocols for organoid culture, maintenance and characterization.
• Drive innovation in experimental workflows and screening methodologies within organoid systems.
• Partner with computational biology, AI/ML and drug discovery teams to analyze and communicate functional genomics data.
• Identify and resolve challenges in assay reproducibility, sample throughput and quality control.
• Independently manage multiple projects and ensure timely delivery of high-quality data.
• Maintain accurate records of experiments, protocols and findings, and contribute to scientific presentations.
• Mentor junior staff and research associates.
• Lead strategic project planning and long-term program development.
• Drive complex cross-functional collaborations with internal and external partners.

Required qualifications

• Ph.D. in Molecular Biology, Genetics, Cell Biology or a related field, with 0-4 years of industry or postdoctoral research experience.
• Strong hands-on experience developing and maintaining organoid model systems, including culture optimization, passaging and characterization.
• Experience with CRISPR-based genetic perturbation approaches (e.g., lentiviral or AAV delivery) in 3D or organoid systems.
• Familiarity with adapting organoid systems to high-throughput screening formats, including automation or miniaturization.
• Ability to troubleshoot technical issues and adapt or optimize protocols.
• Excellent written and verbal communication skills, with a track record of presenting complex results to multidisciplinary teams.
• Demonstrated success working collaboratively in a fast-paced, team-oriented environment.

Nice to have

• Familiarity with perturb-seq, single-cell genomics or spatial omics.
• Experience in data analysis using Python or R.
• Experience in in vivo or in vitro CRISPR screening beyond organoid systems.

Benefits

• Competitive compensation and benefits package.
• Base salary, bonus and equity.
• Open, flexible and friendly work environment.
• Platform to develop long-term careers.
• Summary of Benefits available to all applicants.

Before you apply

• The posting does not accept agency resumes.

About the company

Xaira Therapeutics is a biotech startup using AI to transform drug discovery and development, including generative AI models for protein and antibody therapeutics. It is an equal-opportunity employer.