Scientist II, High Throughput Biology

The role

You will design and run experiments to speed up drug discovery, using functional genomics and synthetic biology. You will build high-throughput screens and work with drug discovery, computational biology and AI protein design teams.

What you will do

• Design, implement and optimize biochemical, molecular and cell-based assays for high throughput screening platform development.
• Scale high-throughput screening strategies for binder discovery in mammalian systems.
• Evaluate and pilot emerging technologies and experimental workflows to enhance discovery capabilities.
• Develop and optimize automated workflows, ensuring data quality, reproducibility and process efficiency.
• Partner with drug discovery, computational biology and AI-based protein design teams to analyze and share screening data insights.
• Independently manage multiple projects and deliver high-quality data on time.
• Maintain accurate records of experiments, protocols and findings.
• Contribute to internal and external scientific presentations.

Required qualifications

• Ph.D. in Immunology, Molecular Biology, Cell Biology, Biochemistry, Functional Genomics or a related field.
• 2-4 years of postdoctoral or industry experience (recent PhD graduates may also apply; job level can be adjusted).
• Proficiency with molecular biology techniques, complex library construction, flow cytometry and cell line engineering.
• Experience with pooled screening and NGS-based readouts, including library preparation and sequencing QC.
• Strong analytical skills and ability to troubleshoot complex experimental issues independently.
• Strong data analysis capabilities, including visualization and statistical software (e.g., GraphPad Prism, R, Python).
• Excellent written and verbal communication skills.
• Ability to work effectively across interdisciplinary teams and drive cross-functional projects.

Nice to have

• Experience with high throughput antibody display technologies, including yeast, phage or mammalian display.
• Familiarity with single-cell genomics workflows (e.g., scRNA-seq, barcoded or multiplexed assays).

Benefits

• Competitive compensation and benefits package.
• Base salary, bonus and equity.
• Open, flexible and friendly work environment.
• Platform to develop long-term careers.
• Summary of Benefits available to all applicants.

Before you apply

• Recruitment agencies are not accepted; unsolicited agency resumes are not the company's responsibility for fees.

About the company

Xaira Therapeutics is a biotech startup using AI to transform drug discovery and development, including generative AI models for protein and antibody therapeutics. It is headquartered in the San Francisco Bay Area, Seattle and London.