Research Associate / Senior Research Associate, Genomic Core

The role

You will prepare sequencing libraries and run Illumina sequencers for the Genomic Core team. You will also support single-cell workflows, quality control, and NGS protocol development for projects across therapeutic areas.

What you will do

• Prepare high-quality sequencing libraries for Illumina platforms using a range of methods.
• Operate and maintain Illumina sequencers, including run setup, monitoring, troubleshooting, and basic maintenance.
• Support and execute single-cell workflows, including 10x Genomics GEM-X and 10x Flex assays.
• Perform QC of input material and libraries and assess data quality after sequencing.
• Collaborate with internal teams to support project-specific NGS needs.
• Troubleshoot experimental issues independently and suggest improvements to protocols and workflows.
• Develop and optimize NGS protocols and contribute to scaling automated or high-throughput sequencing pipelines.
• Contribute to scalable, high-throughput cloning and viral production pipelines.
• Maintain detailed electronic lab notebook records for reproducibility and compliance.
• Run analysis pipelines such as bcl2fastq and CellRanger.

Required qualifications

• B.S. or M.S. in Molecular Biology, Genomics, Biotechnology, or a related field.
• 2+ years of laboratory experience, including direct experience in NGS workflows.
• Proficiency in Illumina sequencing library preparation methods for DNA and RNA.
• Hands-on experience with Illumina sequencer operation and troubleshooting.
• Experience with quality control methods for nucleic acids and libraries.
• Strong organizational skills and meticulous attention to detail.

Nice to have

• Familiarity with single-cell workflows such as 10x Genomics GEM-X and/or Flex assays (strongly preferred).
• Familiarity with library cloning techniques such as vector design, PCR, Gibson or Golden Gate assembly, and bacterial transformation.
• Knowledge of high-throughput or automated NGS library prep platforms.
• Familiarity with cloud-based LIMS or data tracking systems such as Benchling or BaseSpace.
• Basic knowledge of NGS data analysis, including demultiplexing and QC metrics.

Benefits

• Competitive compensation and benefits package.
• Base salary, bonus, and equity.
• Open, flexible, and friendly work environment.
• Platform to develop long-term careers.
• Summary of Benefits available to all applicants.

Before you apply

• Xaira Therapeutics does not accept agency resumes.

About the company

Xaira is an AI-focused biotech startup developing generative AI models to design protein and antibody therapeutics and foundation models for biology and disease. It is headquartered in the San Francisco Bay Area, Seattle, and London.