Senior Scientist, Antibody Characterization

The role

You will support the discovery and development of therapeutic molecules through hands-on, lab-based work. You will characterize and screen antibodies and analyze experimental data for cross-functional teams.

What you will do

• Support the discovery and development of therapeutic molecules through hands-on laboratory work.
• Characterize antibodies in high-throughput manner using BLI and SPR biosensor platforms for binding, kinetics and affinity.
• Screen antibodies and antibody-like molecules for off-target binding using BVP ELISA or other poly-specificity assays.
• Perform early developability assessment on antibody panels using SPR, DLS, DSF, SEC and ELISA.
• Support other workflows as needed, including fluorescence binding assays and assay automation.
• Analyze experimental data, curate results and reports, and present findings to cross-functional teams.
• Maintain experimental records in an ELN.
• Ensure compliance with laboratory safety protocols and contribute to lab organization and operations.

Required qualifications

• PhD in a relevant discipline with 5+ years of industry experience, or BS/MS with 10+ years of industry experience, in biophysics, biochemistry, structural biology or a related field.
• Extensive experience in antibody screening, including monoclonal, bispecific and other antibody-like molecules.
• Extensive hands-on experience with ELISA, BLI and SPR platforms (Carterra, Biacore).
• Basic knowledge of protein production, purification and characterization (affinity, ion exchange, HIC, DLS, DSF, SEC).
• Proficiency in data analysis software (e.g., GraphPad Prism) and statistical tools.
• Proactive, self-starter mindset.
• Strong organizational, communication and interpersonal skills.
• Strong collaborative skills and interest in cross-functional teams and a startup environment.
• Excellent problem-solving and troubleshooting abilities.
• Ability to work independently with accountability and meticulous attention to detail.

Benefits

• Competitive compensation and benefits package.
• Base salary, bonus and equity.
• Open, flexible and friendly work environment.
• Platform to develop long-term careers.
• Summary of Benefits available to all applicants.

Before you apply

• Candidates with fewer years of experience are also encouraged to apply, and the level of the role can be adjusted.

About the company

Xaira Therapeutics is a biotech startup using AI to transform drug discovery and development, including generative AI models for protein and antibody therapeutics. It is an equal-opportunity employer.