Senior Scientist Single Cell Assay and Technology Development

The role

You will invent and develop single-cell assays for AI-driven drug discovery, from concept and feasibility through reproducible, high-throughput workflows. You will work with biologists, engineers and computational scientists on a small, multidisciplinary technology development team.

What you will do

• Conceive, prototype and develop novel single-cell assays and expand commercial workflows
• Develop and troubleshoot assay components from sample prep and barcoding through library preparation and QC
• Design custom primers, oligonucleotides and barcodes
• Build mammalian cell systems and functional assays using flow cytometry, imaging and in situ hybridization
• Partner with biology and engineering teams to turn prototypes into scalable workflows
• Document protocols for transfer to internal teams
• Evaluate emerging technologies

Required qualifications

• PhD in molecular biology, cell biology, bioengineering, biochemistry, immunology or a related field
• 4+ years of relevant experience, including industry experience in assay or technology development (candidates with fewer than 4 years of postdoctoral experience and strong single-cell assay experience
• Track record of inventing or substantially improving single-cell, NGS or cell-based assays
• Expertise in molecular biology and NGS assay development
• Experience with single-cell sequencing workflows
• Strong mammalian cell biology skills, including cell culture and functional assay development
• Strong analytical skills in experimental design and statistical analysis of NGS and single-cell data
• Proficiency in R or Python
• Strong organizational, written and oral communication skills
• Ability to work in a fast-paced, rapidly changing environment

Nice to have

• Antibody engineering, expression, QC, conjugation or functional testing; immunology or primary immune cell assays
• High-throughput or miniaturized assays, lab automation or design of experiments
• Pooled screening, perturbation assays or molecular reporter development with sequencing readouts

Benefits

• Competitive compensation and benefits package
• Base salary, bonus and equity
• Open, flexible and friendly work environment
• Platform to develop long-term careers
• Summary of Benefits available to all applicants

Before you apply

• Xaira Therapeutics does not accept agency resumes

About the company

Xaira is a biotech startup using AI to transform drug discovery, including generative AI models for protein and antibody therapeutics and foundation models for biology and disease. It is headquartered in the San Francisco Bay Area, Seattle and London.