Senior Research Associate, Drug Discovery

The role

You will support drug discovery and development projects by executing biological and bioanalytical assays. The role involves approximately 80% benchtop science to advance drug discovery campaigns.

What you will do

• Work independently and collaboratively with the scientific manager to drive drug discovery and development projects.
• Culture and maintain mammalian cells.
• Manage reagents and working stocks and contribute to general lab maintenance.
• Design, optimize, automate, execute, and troubleshoot cellular, biochemical, and complex in vitro bioassays.
• Standardize and optimize assay protocols and draft assay SOPs.
• Document assay methods, raw data, and results in an electronic laboratory notebook.
• Make presentations and present data at project team meetings.

Required qualifications

• BS or MS in Molecular Biology, Cell Biology, Biochemistry, Bioengineering, or a related discipline
• Minimum of 5 years of industry experience in a drug discovery and/or development setting
• Strong expertise in technical methods in AAV gene therapy for cellular transduction assays (aseptic technique)
• Genome titration (qPCR, ddPCR)
• Transgene expression (RT-qPCR, ddPCR)
• Protein analysis (Western Blot, ELISA, and capillary electrophoresis)
• Good understanding and hands-on experience developing and performing a wide range of analytical and bioassays
• Fluency in data analysis and application of statistical modalities
• Experience in state-of-art assay technologies such as MSD, HTRF, AlphaLISA, Luminex, etc.
• Hands on experience in automation instruments and platforms (e.g. Bravo, Echo, I.DOT, Digital dispenser, etc.)
• Proficient in documenting experimental design, analysis and interpretation of data in ELN
• Excellent data presentation, oral and written communication skills

Nice to have

• Experience working across diverse therapeutic modalities, including viral based gene therapy, mRNA-LNP or other nucleic acid therapeutics, and small molecules
• Background in the field of aging/rejuvenation biology
• Familiarity with assay qualification criteria, processes, and SOP authoring

About the company

Altos Labs is a biotech company whose mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and disabilities. Exceptional scientists and industry leaders work together to advance this shared mission.