Scientist / Senior Scientist, Membrane Biochemistry

The role

You will advance scientific programs on brain aging and neurodegeneration using lipid and protein biochemistry approaches. You will design and implement workflows for protein expression, purification, and characterization.

What you will do

• Design expression constructs and perform recombinant cell culture for membrane protein and membrane-associated protein purification and characterization.
• Evaluate the purity, stability, and physical properties of purified proteins.
• Develop new protein activity assays and establish SOPs.
• Coordinate with CROs for material generation and analysis.

Required qualifications

• PhD in a related field, such as Biochemistry, Chemistry, Biophysics, or Structural Biology
• Demonstrable understanding of biochemistry, including the use of electron microscopy for structural biochemistry.
• Excellent communication skills and proven ability to collaborate within a dynamic team.
• Demonstrated experience with quantitative binding biophysics (BLI, SPR, or ITC), including kinetic and affinity analysis.
• Experience with methods for assessing purity, mass, or stability (mass photometry, SEC-MALS, DLS, analytical SEC, or DSF/thermal stability).
• Experience reconstituting membrane or lipid-associated proteins into liposomes or nanodiscs.
• Experience with Cryo-EM sample preparation and data analysis workflows.
• High level of rigor and precision in experimental design, data recording, and documentation in an ELN.
• A proactive, problem-solving attitude with the ability to independently troubleshoot, manage multiple priorities, and deliver under timelines.

Nice to have

• Experience with AI-assisted protein design pipelines.
• Immunoassay development (ECL/MSD, ELISA).
• Bioconjugation or synthetic chemistry for lipid, glycan, or fluorophore probes.
• Experience with mass spectrometry, NMR, or X-ray crystallography of lipid-protein interactions

About the company

Altos Labs is a biotech company whose mission is to restore cell health and resilience through cell rejuvenation. Exceptional scientists and industry leaders work together to advance a shared mission.