Senior / Principal Scientist, Medicinal Chemistry

The role

You will advance drug discovery programs from hit identification to lead optimization. You will design and synthesize novel compounds and collaborate with cross-functional teams.

What you will do

• Contribute to chemistry efforts for drug discovery programs.
• Design drug-like molecules and optimize compounds.
• Work with Drug Metabolism and Pharmacokinetics, Structural Biology, Biochemical and Cellular Pharmacology, Machine Learning, Pharmaceutical Sciences, Safety, and disease area Biology.
• Apply structure-based, computational, and property-based design tools.
• Synthesize analogs for molecular targets.
• Conduct multi-step syntheses and retrosynthetic analysis.
• Troubleshoot synthetic issues internally or with CRO partners.
• Analyze and communicate structure-activity relationship (SAR) data sets.
• Design compounds addressing potency, physical properties, and ADMET.
• Execute synthesis within internal laboratories and collaborate with CROs.

Required qualifications

• Ph.D. in Organic Chemistry with 6+ years of post-Ph.D. experience, or equivalent and relevant experience in chemical research.
• Proven expertise in modern synthetic organic chemistry.
• Strong track record of lead author publications and/or patents.
• Understanding of medicinal chemistry principles.
• Experience in the drug discovery process from hit identification, hit-to-lead, and lead optimization.
• Experienced with structure-based drug design.
• Strong verbal and written communication skills.
• Ability to deliver effective presentations.
• Expertise and understanding of modern synthetic methodologies, multi-step synthetic route design, compound purification, and characterization.

Nice to have

• Experience within a biotechnology or pharmaceutical setting

About the company

Altos Labs is a company whose mission is to restore cell health and resilience through cell rejuvenation. Exceptional scientists and industry leaders work together to advance a shared mission.