Senior/Executive Medical Director, Clinical Development (New Indications)

The role

This person will lead clinical development strategy and execution for Phase 1 and Phase 2 studies in neurology and new indications. They will shape the clinical portfolio from indication selection through proof-of-concept readout.

What you will do

• Lead design, planning, and execution of Phase 1 and Phase 2 clinical studies for A-005 and other pipeline molecules
• Develop clinical development plans, study synopses, protocols, and integrated development strategies
• Provide clinical and scientific leadership to cross-functional study teams
• Collaborate with Translational Medicine and Research teams to evaluate new indication opportunities
• Serve as Medical Monitor for assigned Phase 1 and 2 studies
• Oversee medical aspects of study conduct including safety surveillance and data review
• Partner with Clinical Operations, Biostatistics, and Regulatory Affairs
• Lead interactions with Data Safety Monitoring Boards
• Contribute to regulatory strategy and serve as clinical representative with FDA and international authorities
• Represent Alumis at scientific conferences, advisory boards, and with Key Opinion Leaders

Required qualifications

• MD required
• Neurology experience required
• 10+ years of pharmaceutical/biotechnology industry experience in clinical development, with a significant focus on neurology
• Demonstrated experience leading Phase 1 and Phase 2 clinical studies from design through data readout
• Track record of successful regulatory interactions (FDA, EMA)
• Experience preparing IND/CTA submissions
• Deep understanding of early clinical development, including dose-finding strategies, biomarker integration, and adaptive trial designs
• Strong scientific acumen
• Excellent leadership, communication, and interpersonal skills

Nice to have

• Board certification or fellowship training in Neurology
• Additional experience in inflammatory disease areas (e.g., rheumatology, dermatology)
• Experience in immunology or autoimmune diseases
• Experience with JAK/TYK2 inhibitors or related immunomodulatory mechanisms
• Experience with indication expansion or lifecycle management for neurology or immunology assets
• Prior experience at a small or mid-sized biotechnology company
• Established relationships with KOLs in neurology
• Relationships in rheumatology, dermatology, or other inflammatory disease areas
• Experience across multiple therapeutic indications, including neurological diseases and/or inflammatory conditions
• Familiarity with regulatory pathways for expedited development (Breakthrough Therapy, Fast Track)

Benefits

• Competitive compensation package including base salary, annual bonus, and equity participation
• Health insurance premiums paid at 90% for employee, 80% for dependents
• Free access to Genentech Bus & Ferry Share program
• $100 monthly cell phone stipend
• Unlimited PTO for Exempt employees
• Free onsite gym
• Kitchen stocked with snacks and drinks

About the company

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases.