Vice President, Translational Medicine

The role

The Vice President, Translational Medicine will shape and execute translational strategy across a portfolio of classical complement biology programs. This leader will partner with Clinical Development, Discovery, Regulatory, Clinical Operations, and Medical Affairs to translate mechanistic hypotheses into human biology evidence and biomarker strategies.

What you will do

• Set an integrated, portfolio-level translational strategy linking mechanism of action to clinical outcomes.
• Partner with program teams to define translational hypotheses and proof-of-concept strategies.
• Build and lead a Translational Medicine organization including biomarker science, bioinformatics, and assay development.
• Develop and oversee computational biology and the use of AI, Machine Learning, and LLMs.
• Develop and execute biomarker strategies for target engagement, pharmacodynamics, and patient stratification.
• Guide biomarker integration into clinical protocols across neurology and ophthalmology programs.
• Oversee the development, qualification, and validation of translational assays.
• Lead translational interpretation and integration of multi-modal datasets.
• Provide translational leadership for GBS, Ophthalmology, and Neurodegeneration programs.
• Contribute to translational sections of regulatory documents and briefing packages.

Required qualifications

• MD, PhD, or MD/PhD
• Minimum of 15 years of experience in pharma or biopharma with leadership responsibility in Translational Medicine, Biomarkers, and/or Clinical Development interfaces.
• Proven track record leading translational medicine organizations.
• Proven track record building and leading translational bioinformatics capabilities.
• Proven track record applying machine learning and advanced computational methods to translational datasets.
• Proven track record utilizing observational cohorts, natural history studies, real-world data, and external control datasets.
• Deep domain expertise in one or more of the following: Neurology / Neuroimmunology, Ophthalmology, or Immunology/Rheumatology.
• Demonstrated expertise in translational disciplines including biomarker strategy, assay development/qualification, clinical sample strategy/operations, and quantitative translational data integration,
• Strong leadership and interpersonal skills.
• Willingness to be In Office on a regular basis.
• Excellent communication and presentation skills.

Nice to have

• Advanced clinical/scientific training
• Experience across multiple domain expertise areas
• Experience supporting successful regulatory filings
• Experience with companion diagnostic development

Benefits

• Flexible work schedules
• Remote opportunities
• Ability to achieve a work-life balance
• Shuttle service from BART, CalTrain and the Ferry
• Competitive base salary
• Equity participation
• Employee stock purchase plan
• Medical
• Dental
• Vision
• 401(k)
• Flexible spending plans

About the company

Annexon Biosciences is a biopharmaceutical company advancing a late-stage clinical platform of novel therapies for classical complement-mediated neuroinflammatory diseases. The company is headquartered in Brisbane, CA.