Research Scientist, Life Sciences (Large Molecules, Antibody Design)

The role

You will design and engineer therapeutic antibodies and oversee programs from target selection to IND-enabling studies. You will work with AI researchers to close the loop between AI-generated hypotheses and experimental data.

What you will do

• Design and engineer therapeutic antibodies and oversee programs end to end
• Define the screening cascade for each program
• Plan the path from lead to IND-enabling studies
• Coordinate antibody production, characterization, and studies with external partners
• Evaluate AI-designed antibodies and feed results back to research teams
• Ensure experimental data across programs is high quality and well documented
• Communicate findings clearly to biology, AI research, and life sciences audiences

Required qualifications

• PhD in biochemistry, protein engineering, immunology, molecular biology, or a related field
• Demonstrated experience in therapeutic antibody discovery and engineering
• Experience taking at least one antibody from discovery through candidate selection and IND-enabling studies
• Working knowledge of what an antibody IND requires across pharmacology, pharmacokinetics, toxicology, and CMC
• Comfort navigating ambiguity and defining problems in a rapidly evolving research environment
• Ability to work independently while collaborating effectively across cross-functional teams
• Strong written and verbal communication skills

Nice to have

• 5+ years of therapeutic antibody experience beyond the PhD
• Track record of advancing more than one antibody program into IND-enabling studies or the clinic
• Hands-on experience with antibody expression, purification, and biophysical characterization
• Experience directing antibody production, assays, and in vivo studies at contract research organizations
• Structural biology, computational protein design, or coding skills
• Experience using AI or ML tools in the life sciences
• Publications and/or patents demonstrating scientific impact

Benefits

• Competitive compensation and benefits
• Optional equity donation matching
• Generous vacation and parental leave
• Flexible working hours
• Office space

Before you apply

• We do sponsor visas

About the company

Anthropic is a public benefit corporation headquartered in San Francisco. Their mission is to create reliable, interpretable, and steerable AI systems.