Medicinal Chemistry Project Leader

The role

The Medicinal Chemistry Project Leader leads chemistry efforts within a cross-functional team to drive preclinical programs toward key decisions. This role focuses on designing molecules with optimized potency, selectivity, and pharmacokinetic properties, specifically emphasizing degrader-antibody conjugates.

What you will do

• Drive milestone decision-making on assigned PROTAC projects from inception to clinical candidate nomination
• Perform molecular and synthetic design of PROTACs, degrader-antibody conjugates, and libraries
• Conduct SAR analysis of complex, multivariate datasets to generate new hypotheses
• Interact with external CRO resources to ensure synthetic and data needs are met
• Solicit and analyze experimentation and data to prioritize issues and meet goals
• Collaborate and communicate with other functions in drug discovery
• Provide scientific updates to manager and company executives
• Represent company interests at conferences and with external organizations
• Craft and communicate data-based strategic recommendations to R&D leadership

Required qualifications

• PhD in organic chemistry or medicinal chemistry
• 8+ years of pharma/biotech-based drug discovery experience
• Proven track record of leading research projects through milestone decisions toward clinical candidate nomination
• Extensive experience in the synthetic and medicinal chemistry of antibody-drug conjugates
• Extensive knowledge around structure-based design, SAR generation, and multi-parametric optimization
• Deep understanding of pharmacokinetic principles and in vivo pharmacology
• Proven ability to collaborate and communicate project needs and strategy to multidisciplinary team members and senior leaders
• Legally authorized to work in the US without the need for employer sponsorship now or at any time in the future
• Ability to lift/carry 15/30 pounds unassisted/assisted
• Ability to work in a controlled environment with biological, infectious and hazardous materials
• Ability to gown/degown PPE
• Maintain general availability during standard business hours

Nice to have

• Specific experience with degrader-antibody conjugates

Benefits

• Base and incentive compensation
• Group medical, vision and dental coverage
• Group and supplemental life insurance

Before you apply

• Must be legally authorized to work in the US without the need for employer sponsorship now or at any time in the future

About the company

Arvinas is a biotechnology company that uses its proprietary PROTAC Discovery Engine platform to develop therapies that degrade disease-causing proteins. The company is headquartered in New Haven, Connecticut.