Director/Senior Director, HEOR Modeling and Evidence Synthesis

The role

This person will serve as a senior technical expert for health economic modeling and comparative evidence generation. They will conceptualize, build, validate, and communicate models supporting marketed products and pipeline assets for CNS conditions.

What you will do

• Develop health economic models including cost-effectiveness, budget impact, and decision trees
• Lead scientific strategy and execution of cost-effectiveness and disease models
• Lead systematic literature reviews and formal network meta-analyses
• Partner with cross-functional teams to translate evidence into payer-relevant materials
• Provide model-based insights for pricing, access strategy, and clinical development
• Serve as internal technical authority on ICER methods and economic model critique
• Establish modeling and evidence-synthesis standards and templates
• Communicate complex methods and findings to technical and non-technical audiences

Required qualifications

• PhD, PharmD, MD, DrPH, or relevant Master’s degree in health economics, economics, operations research, decision science, epidemiology, biostatistics, public health, outcomes research, or a related qu
• 10+ years of relevant HEOR, health economic modeling, and evidence-synthesis experience in pharmaceutical, biotechnology, medical device, consulting, or academic setting
• Substantial experience supporting biopharmaceutical products
• Demonstrated record of independently leading multiple complex economic models
• Demonstrated understanding of the Medicare & Medicaid ecosystem
• Demonstrated hands-on experience with U.S. ICER assessments
• Demonstrated experience conducting systematic literature reviews and formal network meta-analyses
• Strong track record of peer-reviewed publications and scientific presentations
• Advanced proficiency developing transparent, auditable models in Microsoft Excel
• Ability to work on site Monday, Tuesday & Thursday

Nice to have

• Experience with long-term care evidence, coverage, or decision-making
• Proficiency in R and/or other relevant statistical or simulation software
• VBA, Python, TreeAge, or specialized simulation software experience
• Experience designing or conducting analyses using administrative claims and/or electronic health records
• Launch and lifecycle-management experience
• Neuroscience experience

Benefits

• Annual bonus
• Significant equity
• Generous benefits package

About the company

Axsome Therapeutics is a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) conditions. Their neuroscience portfolio includes FDA-approved treatments for major depressive disorder, agitation associated with dementia due to Alzheimer’s disease, excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea, and migraine.