Postdoctoral Fellow/ Scientist I, T Cell Biology and Tissue Immunology

The role

This person will investigate cellular and molecular mechanisms regulating immune cell responses and interactions within tissue microenvironments. The work involves designing in vivo mouse model experiments and applying advanced approaches like single-cell sequencing and spatial transcriptomics.

What you will do

• Investigate the cellular and molecular mechanisms regulating immune cell responses and interactions within tissue microenvironments.
• Design and perform in vivo experiments using mouse models.
• Characterize immune cell differentiation, function, and interactions with other cells.
• Apply advanced experimental approaches, including molecular biology, single-cell sequencing, spatial transcriptomics, and genetic perturbation technologies.
• Develop and test hypotheses to understand how immune cells and local tissue environments reciprocally shape each other’s behavior and function.
• Work collaboratively with experimental and computational scientists across Biohub to integrate cellular, molecular, and spatial datasets.
• Design, execute, and analyze experiments independently.
• Present scientific findings at meetings and conferences and prepare manuscripts for publication.
• Contribute to the scientific development of the laboratory and mentor junior researchers.

Required qualifications

• PhD in molecular biology, bioengineering, genetics, cell biology, immunology, or a related field.
• 3+ years experience with demonstrated impact in experimental molecular and cellular biology.
• 2+ years of post PhD experience for Scientist position
• Demonstrated experience with mouse models, and tissue processing.
• Hands-on experience with molecular cloning, genetic engineering, or genetic perturbation approaches.
• Experience designing, optimizing, and troubleshooting complex experimental workflows.
• Demonstrated ability to independently design, execute, and interpret experiments.
• Strong scientific curiosity, creativity, and problem-solving skills.
• Excellent communication and collaborative skills.
• Interest in applying engineering and functional genomics approaches to understand complex biological systems.

Nice to have

• Experience with scalable genetic perturbation approaches, including pooled CRISPR screens, in vivo perturbation strategies, or functional genomics.
• Experience studying immune cell differentiation, activation, migration, or effector function.
• Experience with mouse disease models.
• Experience with single-cell RNA sequencing, spatial transcriptomics, or other high-dimensional genomic technologies.
• Experience with molecular cloning, viral vector engineering, or genetic manipulation of mammalian cells.
• Experience with advanced flow cytometry, cell sorting, or imaging techniques.
• Experience analyzing high-dimensional immunological datasets.

Benefits

• Generous employer match on employee 401(k) contributions
• Paid time off to volunteer at an organization of your choice
• Funding for select family-forming benefits
• Relocation support for employees who need assistance moving

About the company

Biohub is a large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof to accelerate scientific discovery. It brings together Columbia University, The Rockefeller University, and Yale University into a single collaborative technology and discovery engine.