Senior Director, Clinical Pharmacology

The role

This role leads clinical pharmacology and pharmacometrics strategies on cross-functional teams. You will oversee the design and application of various models for clinical drug development programs and manage external bioanalytical CROs.

What you will do

• Develop and implement clinical pharmacology and pharmacometrics strategies across all stages of clinical development including pediatric development programs.
• Manage the design, development, and application of NCA, population PK, exposure–response, PK/PD, and PBPK models.
• Oversee modeling and simulation-based analyses to support dose selection and study design for clinical trials in pediatric populations.
• Support global regulatory submissions and labeling.
• Author and contribute to clinical pharmacology sections of regulatory documents.
• Support interactions with global regulatory agencies.
• Design clinical pharmacology studies and manage study execution and CROs/vendors.
• Conduct PK data analyses and provide study-level oversight.
• Present results to internal teams and external stakeholders.
• Contribute to scientific publications, abstracts, and conference presentations.

Required qualifications

• Ph.D. or Pharm.D. in Clinical Pharmacology, Pharmaceutical Sciences, or a related discipline
• 10+ years of relevant experience in the biotechnology or pharmaceutical industry
• Track record in population PK, PK/PD, mechanistic modeling (e.g., PBPK), and quantitative data analysis
• Understanding of global regulatory guidances related to clinical pharmacology, model-informed drug development, bioanalytical method validation, and GLP/GxP regulations
• Analytical, critical thinking, and problem-solving skills
• Written, verbal, and interpersonal communication skills

Nice to have

• experience in pediatric drug development

Benefits

• Market-leading compensation
• 401(k) with employer match
• Employee Stock Purchase Program (ESPP)
• Pre-tax commuter benefits (transit and parking)
• Referral bonus for hired candidates
• Subsidized lunch and parking on in-office days
• 100% employer-paid medical, dental, and vision premiums for you and your dependents
• Health Savings Account (HSA) with annual employer contributions
• Flexible Spending Accounts (FSA)
• Fertility & family-forming benefits
• Expanded mental health support
• Flexible, “take-what-you-need” paid time off and company-paid holidays

About the company

BridgeBio uses a model that pools projects and early-stage research from academia to reduce risk and develop medicines for rare diseases. The company values curiosity, experimentation, and the use of AI to improve work quality.