Principal Hardware Engineer - Pleasanton, CA

The role

You will lead the development of advanced fluidic subsystems for kidney stone treatment. This role involves designing and controlling irrigation and aspiration systems using pumps, valves, sensors, and embedded software.

What you will do

• Own and architect end-to-end fluid control systems
• Define and drive development of control algorithms
• Define system/sub-system performance requirements
• Perform system modeling, trade studies, prototyping and bench testing
• Contribute to mechanical/electromechanical design and provide design reviews
• Lead cross-functional alignment across internal teams and external partners
• Collaborate with Systems & Test Engineering for design verification
• Lead hardware sub-system risk management activities
• Organize system/sub-system-level technical design reviews
• Collaborate with suppliers and internal operations for root cause investigation

Required qualifications

• Bachelor’s degree in Mechanical Engineering, Biomedical Engineering, Electrical Engineering, Mechatronics, or a related discipline
• 15+ years of experience developing fluidic, mechatronic, or control systems in a regulated product environment
• Experience with owning end-to-end hardware system architectures for fluidic control systems
• Proven experience developing and tuning closed-loop control systems for electromechanical hardware
• Experience prototyping and testing systems at the bench and subsystem level
• Proficiency with prototype embedded software development (e.g., C/C++, Python, or similar)
• Strong first-principles thinker with expert-level fundamentals in fluid dynamics
• Ability to design experiments, analyze data, and translate results into design improvements
• Clear technical communication skills
• Experience leading external vendors and contract development firms
• Exceptional structured problem-solving skills
• Prior work on medical devices or other safety-critical products, including knowledge of IEC 60601, ISO 13485, and medical device design controls

Nice to have

• Master’s or PhD in a relevant engineering discipline
• Familiarity with disposable fluidic component design and reusable/disposable system interfaces
• Experience with irrigation and aspiration systems, endoscopic or urological devices, or surgical fluid management platforms
• Experience with pressure, flow, air-in-line, or occlusion detection

Benefits

• Competitive base salary
• Variable incentive plan
• Stock options
• 401(k)
• Healthcare insurance
• Paid vacation

Before you apply

• Legal authorization to work in the United States is required
• All persons hired will be required to verify identity and eligibility to work in the United States

About the company

Calyxo, Inc. is a medical device company headquartered in Pleasanton, California, USA. The company was founded in 2016 to address the profound need for improved kidney stone treatment.