Principal Software Engineer - Agentic Platform

The role

You will own the agentic platform end to end, building a durable orchestration layer for multi-stage scientific workflows. You will architect distributed systems, define SDK abstractions, and deliver infrastructure-as-code to move agentic AI from research to production.

What you will do

• Own the agentic platform from research prototype to production.
• Build the durable orchestration layer for long-running, multi-stage scientific workflows.
• Architect workflow orchestration, evaluation frameworks, and event-driven distributed systems.
• Define SDK abstractions and API contracts.
• Deliver infrastructure-as-code reference implementations.
• Transform exploratory AI proof-of-concepts into hardened, reusable patterns.
• Own platform cost-efficiency and scalability.
• Explore and template agent design and deployment patterns.
• Set technical standards, code quality, and architectural direction.
• Partner across teams and mentor engineers and scientists.

Required qualifications

• B.S. or M.S. in Computer Science, Engineering, or a related field
• 10+ years of professional software development experience
• Track record architecting and maintaining large-scale distributed systems in production
• Deep expertise in workflow orchestration and event-driven architecture
• Strong cloud-native engineering on AWS with infrastructure-as-code, containerization, and autoscaling
• Ability to take systems from prototype to hardened, observable, operationally excellent production
• Experience designing SDKs, APIs, and data contracts
• Excellent communication skills
• Collaborative and empathetic working style
• Track record setting technical strategy and direction and mentoring engineers

Nice to have

• Hands-on experience with agentic AI and orchestration frameworks (e.g., Pydantic AI, LangGraph, LangChain, CrewAI, AutoGen)
• Experience integrating LLMs and model platforms, including Anthropic, OpenAI, Vertex AI, and Amazon Bedrock
• Experience building evaluation and feedback-loop frameworks for agentic systems
• Familiarity with sandboxed code execution and agent harness development
• Experience with LLM observability and monitoring tooling and cost-governance / FinOps for AI infrastructure
• Background in scientific domains such as biology, chemistry, or complex systems

Benefits

• Healthcare coverage
• Annual incentive program
• Retirement benefits
• Broad range of other benefits

About the company

Pioneering Intelligence builds on Flagship Pioneering’s legacy of founding cutting-edge science and computational ventures. It transforms breakthrough ideas into world-changing companies in human health, sustainability, and beyond.