Director, Pharmacology

The role

This role connects biology, pharmacology, DMPK, and translational science across inflammation and hematology programs. The person will lead preclinical pharmacology strategy and drive programs from early discovery through candidate selection.

What you will do

• Lead preclinical pharmacology strategy across multiple discovery programs.
• Drive PK/PD interpretation, exposure-response assessment, target coverage analysis, and translational biomarker strategy.
• Integrate data across biology, pharmacology, medicinal chemistry, and DMPK.
• Oversee outsourced pharmacology studies and manage external CRO relationships.
• Partner with internal scientific teams to define critical experiments and interpret data packages.
• Provide strategic input to cross-functional program discussions.
• Represent pharmacology at internal scientific and program meetings.
• Contribute to the development of broader translational approaches.

Required qualifications

• PhD in biology, pharmacology, or a related scientific discipline
• 10-15+ years of relevant experience in biotech or pharmaceutical drug discovery and development
• Strong foundation in preclinical pharmacology with experience translating biology into in vivo efficacy and PK/PD insight
• Experience connecting in vitro findings to in-vivo outcomes, including target engagement, exposure-response relationships, and translational biomarker strategy
• Exposure to DMPK and ability to partner effectively with DMPK scientists
• Proven track record of working across biology, chemistry, pharmacology, and external collaborators
• Experience managing and interpreting outsourced pharmacology studies through CROs
• Strong scientific judgment, data integration skills, and ability to build decision-enabling narratives
• Excellent written and verbal communication skills

Nice to have

• Experience in hematology, particularly in combination with oncology
• Experience supporting inflammation or immunology programs
• Strong publication record spanning pharmacology, translational biology, medicinal chemistry, chemical biology, or drug discovery
• Experience working in smaller, cross-functional biotech environments
• Demonstrated ability to grow into broader translational leadership over time

Benefits

• Healthcare coverage
• Annual incentive program
• Retirement benefits
• Broad range of other benefits

About the company

Cellarity is a privately held, clinical-phase drug discovery startup using AI and single-cell omics to develop medicines. It is a product of Flagship Pioneering's venture creation engine.