(Senior) Scientist, Translational Biology

The role

The Scientist will design and execute complex in vitro and in vivo experiments to support research programs. This role involves performing flow cytometry, primary cell isolation, microscopy, and siRNA-based approaches to advance therapeutic programs.

What you will do

• Design, execute, and analyze complex in vitro / in vivo experiments
• Lead and perform multi-parameter flow cytometry assays
• Perform and optimize primary cell isolation from tissues
• Perform and interpret microscopy-based assays
• Support mouse studies including disease models, dosing, and tissue collection
• Develop and apply siRNA-based approaches
• Analyze and interpret data and generate reports
• Collaborate with internal and external stakeholders
• Mentor junior scientists
• Maintain accurate experimental records

Required qualifications

• Ph.D. in Molecular Biology, Cell Biology, or a related field with 3–6+ years of relevant experience, or M.S. with significant experience
• Strong expertise in flow cytometry, including cell sorting (FACS), panel design, troubleshooting, and data analysis
• Hands-on experience with primary cell isolation techniques from mouse tissue
• Hands-on experience with microscopy techniques and associated image analysis software
• Demonstrated experience with siRNA design, delivery, and functional validation
• Strong data analysis and problem-solving skills
• Excellent communication and presentation skills
• Ability to work independently and collaboratively in a fast-paced environment

Nice to have

• Experience with mouse models, including in vivo study design, dosing, and tissue collection
• Experience in translational or preclinical research environments
• Experience with cold-active or optimized dissociation protocols for isolating sensitive/rare cell types
• Experience with advanced imaging modalities
• Familiarity with additional molecular techniques (qPCR, Western blot, ELISA, RNA-seq, gene silencing, protein over-expression)
• Experience working in a biotech or pharmaceutical setting

Benefits

• Healthcare coverage
• Annual incentive program
• Retirement benefits
• Broad range of other benefits

About the company

FL106 Inc. is a privately held, early-stage biotechnology company focused on developing novel drug delivery modalities. It is backed by Flagship Pioneering.