Senior Scientist, Bioanalytical Sciences

The role

You will lead the development, qualification, and implementation of immunogenicity and ligand binding assays. This role involves characterizing innate immune responses to nucleic acid modalities and managing junior scientists.

What you will do

• Design, develop and execute cell-based immunoassays, flow cytometry based assays and LBAs
• Apply knowledge of innate immunology to establish in vitro screening assays
• Collaborate with CMC, molecular biology and cell biology teams
• Ensure development, qualification, and validation of bioanalytical assays
• Design, optimize, and execute biodistribution studies
• Design, establish and execute assays for assessing in vivo immunogenicity predictors
• Design, develop, optimize, and execute bioanalytical assays to support nonclinical studies
• Execute test procedures such as sample extraction and measurement
• Analyze and summarize scientific data and maintain electronic lab notebooks
• Mentor, coach, and manage junior scientists

Required qualifications

• Ph.D. in immunology, biochemistry, pharmaceutical sciences, cell biology or related field
• 5 plus years of industry experience
• Demonstrated expertise in innate immune signaling and nucleic acid sensing pathways for DNA and mRNA
• Proficiency in multicolor flow cytometry, ddPCR, ligand binding assays, leukopak processing and isolation of PBMCs
• Experience developing bioanalytical methods to measure drugs and biomarkers for LNP delivery of nucleic acid cargoes
• Experience managing junior scientists
• Strong communication, presentation and interpersonal skills
• Attention to detail, strategic thinking, problem solving, and decision-making skills

Nice to have

• Experience with LNPs, and nucleic acid modalities

Benefits

• healthcare coverage
• annual incentive program
• retirement benefits
• broad range of other benefits

About the company

Serif Biomedicines is a privately held, early-stage biotechnology company developing a novel approach to gene therapy. It was founded by Flagship Pioneering, an innovation enterprise that creates life sciences companies.