Scientist I, In Vitro Pharmacology

The role

The candidate will develop and execute biochemical and cell-based assays to support the progression of the Syntein pipeline. This role involves collaborating cross-functionally with design-make-test teams and occasionally contributing to in vivo and ex-vivo pharmacology activities.

What you will do

• Design and execute cell-based and biochemical assays to assess Syntein activity, target engagement, and mechanism of action
• Conceptualize and develop novel assays for diverse target classes and disease areas
• Collaborate with the Pharmacology team on biochemistry and biophysics projects
• Contribute to in vivo and ex vivo pharmacology activities
• Collaborate cross-functionally to enable novel methods, assays and screening workflows
• Optimize assays for incorporation into screening funnels
• Cross-train colleagues on methods
• Ensure rapid generation and accurate reporting of high-quality data
• Collaborate with Computational Design and Chemistry & Screening teams
• Communicate scientific findings and ideas to a diverse team

Required qualifications

• PhD in molecular or cell biology or related discipline with up to 2 years relevant experience
• Technical expertise with mammalian cell culture including establishing and maintaining cell lines, transient and stable transfection, lentiviral transduction, and reporter cell lines
• Proficient in industry-standard cell-based assays and bioanalytical techniques including TR-FRET, Lumit, ELISA, Western blot, flow cytometry, enzymatic activity, and reporter gene assays
• Experienced with primary cell culture and characterization, including tissue dissociation
• Experienced in assay development and testing in model systems and human
• Understanding of analytical and pre-analytical methods and solutions
• Ability to independently design, develop and optimize diverse cell-based functional assays
• Ability to interpret complex results
• Industry level experience with best practices related to data records creation and maintenance and workflow integrity
• Ability to work in a fast-paced environment

Nice to have

• industry experience
• experience with cellular/high content imaging and image analysis (e.g., Incucyte, Phenix)
• Strong proficiency in renal disease biology and preclinical kidney models
• In vivo pharmacology experience
• Proficiency in laboratory automation and semi-automated screening workflows

Benefits

• healthcare coverage
• annual incentive program
• retirement benefits
• broad range of other benefits

About the company

Abiologics, Inc. is a privately held, early-stage biotechnology company on a mission to make biology better through an innovative therapeutic modality. It was founded in Flagship Pioneering’s venture creation engine.