Senior Machine Learning Scientist

The role

You will build models and AI agents to turn somatic mutation data into evidence for target discovery. You will develop models of variant effects on protein function and create agentic AI workflows to support scientific analysis.

What you will do

• Build and evaluate models that predict how coding and non-coding variants affect protein function, stability, interactions and pathway activity
• Use variant-effect predictions to interpret somatic selection signals
• Design, build and evaluate AI agents and agentic workflows
• Train, fine-tune or adapt foundation models, language models and representation-learning methods
• Use AI coding tools to speed up development
• Work as a core member of cross-functional project teams
• Communicate results clearly to scientists and target discovery leadership

Required qualifications

• PhD in machine learning, computer science, computational biology, genomics, bioinformatics, statistics, engineering or a related field, or an MSc with equivalent experience
• Strong Python skills and experience building practical deep learning systems (e.g. PyTorch, JAX)
• Experience training, evaluating or applying ML models to complex real-world biological data
• Understanding of how genetic variants affect protein structure and function
• Experience with variant-effect prediction methods (e.g. protein language models such as ESM, structure-based models, or tools such as AlphaMissense)
• Regular use of AI coding assistants, LLM-based workflows or agentic development tools in your own work
• Proven ability to work in cross-functional teams and to explain technical results to non-specialists
• Evidence of technical depth through papers, thesis work, open-source projects, industry projects or substantial applied research

Nice to have

• Depth in one or more of the following: biomedical foundation models, AI agents, Perturb-seq or single-cell genomics, genotype–phenotype modelling, causal inference, perturbation modelling, or large-sc

About the company

Quotient Therapeutics is a Flagship Pioneering company that uses somatic genomics to discover drug targets. It is a privately-held, early stage company developing breakthrough medicines informed by natural somatic genetic diversity present in patients.