FL114: Senior Scientist, Therapeutics Engineering

The role

The candidate will drive product generation and support therapeutic programs as part of the Therapeutics Engineering team. They will conduct cellular screening assays, characterize novel biologics, and manage external partners.

What you will do

• Independently conduct, optimize and proactively troubleshoot cellular screening assays in a wide range of primary and transformed cell lines.
• Expression and functional characterization of novel biologics modalities using various cell systems and techniques.
• Drive, pilot, and oversee development of a wide range of cutting-edge assays.
• Design, procurement, and maintenance of plasmids or other relevant materials for cell-based and cell-free assays.
• Identification and management of external partners (CROs, CMOs, etc).
• Execute routine and advanced molecular biology techniques.
• Culture and maintain a wide variety of mammalian cell lines.
• Analyze and interpret assay data and maintain accurate laboratory notebooks.
• Drive optimization and automation of screening protocols using liquid handling systems and plate readers.

Required qualifications

• PhD in Cell or Molecular Biology, Biochemistry, or related disciplines with 2+ years of relevant experience in biotech or pharma.
• Strong background in cellular and molecular biology with hands-on experience in the development and optimization of cell-based assays and library screening assays.
• Extensive experience in gene design, vector construction, and protein expression.
• Strong communication skills, both written and verbal.
• Execute routine and advanced molecular biology techniques, including plasmid preparation, RT-qPCR, cloning, RNA/DNA extraction, gel electrophoresis, oligo pool work, etc.
• Culture and maintain a wide variety of mammalian cell lines, including transient and stable transfections.
• Develop cell lines as necessary.
• Analyze and interpret assay data.
• Drive optimization and automation of screening protocols, including the use of liquid handling systems and plate readers.
• Experience developing DNA assets for molecular library design.
• Experience with gene delivery technologies (for example LNP, lentivirus, etc.).
• Exposure to CRISPR-based or other gene editing technologies.

Nice to have

• Industry experience in drug discovery or pharmaceutical R&D preferred

Benefits

• healthcare coverage
• annual incentive program
• retirement benefits
• a broad range of other benefits

About the company

FL114 is an innovative, privately held biotechnology company developing a novel epigenetic editing platform to treat a variety of diseases. It was founded by Flagship Pioneering.