Senior Research Associate, In Vivo Pharmacology

The role

The Senior Research Associate will execute rodent in vivo studies and coordinate studies with contract labs. They will also contribute to in vitro and ex-vivo pharmacology activities including molecular and cell biology assays and histology.

What you will do

• Conduct in vivo (mouse) studies to characterize function, pharmacokinetics, and biodistribution of Synteins TM
• Perform hands-on dosing of mice and isolation/processing of mouse blood and tissues
• Comply with IACUC regulations regarding animal welfare and care
• Collect and prepare tissues for histology, including fixation and embedding
• Execute and optimize lab procedures such as tissue lysis, cell isolation, ELISA, Western blot, RNA/DNA extraction, and qPCR
• Coordinate with CROs to support external in vivo studies
• Analyze, interpret, and document study and assay results in an electronic lab notebook
• Present findings in internal meetings
• Apply troubleshooting and data analysis skills to improve study quality
• Collaborate with the Pharmacology team to support lead optimization and platform advancement

Required qualifications

• BS in Biology or related discipline with 5–7 years of relevant research experience, or MS with 3–5 years of relevant experience
• Independent experience with rodent in vivo dosing and handling techniques
• Expertise in multiple routes of substance administration (e.g., PO, IP, IV, SC)
• Ability to execute study protocols involving multiple blood collection time points
• Experience in tissue dissection and preparation for RNA, protein analysis, and histology
• Ability to execute or learn molecular and cell biology techniques such as ELISA, Western blot, qPCR, cell-based functional assays, and flow cytometry
• Proficiency with Excel, GraphPad Prism, and PowerPoint

Nice to have

• Extensive experience in cell culture techniques, including primary cell isolation, culture, characterization
• Experience with tissue sectioning and immunohistochemistry techniques, including antibody validation, multiplexing, and imaging
• Experience in flow cytometry and data analysis (e.g., FlowJo)

Benefits

• healthcare coverage
• annual incentive program
• retirement benefits
• broad range of other benefits

About the company

Abiologics, Inc. is a privately held, early-stage biotechnology company on a mission to make biology better through an innovative therapeutic modality. It was founded in Flagship Pioneering’s venture creation engine.