Associate Director, LNP Manufacturing

The role

This person will lead a team of scientists and engineers to ideate and build the next generation of Programmable Medicines. They will lead LNP scale-up from small R&D formulations to NHP scale and drive process development.

What you will do

• Lead LNP scale-up from small R&D formulations to NHP scale in support of a development candidate.
• Drive upstream and downstream process development, including mixing platforms, TFF, and freeze/storage buffer optimization.
• Scale targeted LNPs, including conjugation, purification, and associated analytics.
• Run micro- to mid-scale formulation on microfluidics platforms to support platform advancement.
• Integrate QC profiling and method development into process development.
• Lead and mentor a team of scientists and engineers.
• Partner across departments to deliver for in vivo studies.

Required qualifications

• Ph.D. in chemistry, chemical engineering, biochemistry, or biomedical engineering
• Relevant industry experience
• Hands-on experience scaling nucleic acid LNP formulations across upstream, downstream, and analytics
• Working knowledge of mixing platforms (T-mix, impingement, microfluidics) and TFF
• Familiarity with LNP analytical methods (DLS, HPLC/CAD, LC-MS, encapsulation assays)
• Solid understanding of lipid and LNP design principles, stability, and their impact on critical product attributes
• General understanding of molecular biology and nucleic acid therapeutics
• Experience managing and mentoring research associates and junior scientists

Nice to have

• Experience scaling in a GMP environment and managing CDMOs
• Experience taking LNPs to the clinic, including agency interactions
• Experience with tLNP conjugation at scale
• Lipid synthesis, purification, and compositional analysis

Benefits

• Healthcare coverage
• Annual incentive program
• Retirement benefits
• A broad range of other benefits

About the company

Serif Biomedicines is a privately held, early-stage biotechnology company developing a novel approach to gene therapy. It was founded by Flagship Pioneering, an innovation enterprise that creates and grows life sciences companies.