Scientist I, Biochemistry & Lead Discovery

The role

This scientist will lead assay development, target engagement studies, and binding characterization for small molecules and related modalities. The role involves working with chemistry and biology to inform hit-to-lead optimization and mechanism-of-action questions.

What you will do

• Lead and execute biochemical assay development to monitor protein/ligand and protein/protein interactions
• Apply readout technologies such as FP, FRET, NanoBRET, or NanoBiT across active programs
• Drive protein purification and QC processes to support ongoing discovery efforts
• Set up and run high-throughput assays
• Troubleshoot assays independently
• Partner with contract research organizations as needed
• Collaborate cross-functionally and contribute scientific input across multiple concurrent projects

Required qualifications

• MS or PhD in Biochemistry, Chemical Biology, Enzymology, or a related field
• MS and at least 8 years of relevant academic or industry experience, or PhD and 0-2 years of relevant academic or industry experience
• Deep understanding of protein chemistry and biophysics
• Hands-on experience working with small-molecule compounds
• Demonstrated ability to develop and troubleshoot biochemical assays independently
• Excellent communication skills
• Ability to work cross-functionally
• High degree of scientific independence, motivation, and solutions-oriented thinking
• Comfort operating in a fast-paced environment with shifting priorities

Nice to have

• Experience working with CROs

Benefits

• healthcare coverage
• annual incentive program
• retirement benefits
• broad range of other benefits

About the company

Flagship Labs 111 Inc. (FL111) is a privately held, early-stage biotechnology company pioneering a novel platform harnessing innovations in chemistry, computation, and data science. It is backed by Flagship Pioneering.