Sr. Scientist, Protein & Cell Sciences

The role

This person will run and optimize the engine that turns computationally designed antibodies into well-characterized, developable therapeutic proteins. The role focuses on protein expression, purification, and analytical characterization to support platform development and therapeutic discovery programs.

What you will do

• Design and execute workflows for recombinant protein production, including transient mammalian expression, purification, and quality assessment.
• Contribute to the design, execution, and troubleshooting of experiments that improve throughput, reproducibility, and data quality.
• Partner closely with Antibody Discovery, Antibody Engineering, Computational Biology, and other cross-functional teams.
• Serve as a mentor to junior team members and a subject matter expert in recombinant production and protein stability metrics.
• Establish and maintain strong documentation practices, experimental rigor, and reproducible workflows.
• Prepare study reports, summarize data, and present results clearly to internal stakeholders.
• Support continuous improvement of lab operations, including the adoption of new methods, tools, and workflows.

Required qualifications

• PhD (or BS/MS degree with equivalent level of experience) in protein biochemistry, molecular biology, chemical engineering, structural biology, analytical chemistry, or a related field with 5+ years o
• Experience in protein production, purification, and analytical characterization in a biotechnology or pharmaceutical setting responsible for regular production of milligram to grams of material on a r
• Strong hands-on experience with mammalian cell culture and transient transfection.
• Proficiency with protein purification systems (FPLCs and Autosamplers) and analytical systems (UHPLCs) used to assess protein quality and function.
• Experience with biophysical characterization methods such as BLI, SPR, DSF, DLS, or related approaches.
• Demonstrated ability to design, troubleshoot, and optimize experiments independently.
• Strong organizational skills, scientific rigor, and written and verbal communication skills and a record of establishing robust systems
• Ability to work effectively in a fast-paced, collaborative, cross-functional environment.

Nice to have

• Experience with antibody discovery workflows and biologics development.
• Experience with automated multi-step midscale purification.
• Experience with production from linear DNA templates.
• Experience with bi and multi specific antibody formats.
• Experience managing direct reports or mentoring junior scientists.
• Familiarity with data capture systems and structured documentation practices.
• Exposure to assay development and validation for discovery or translational applications.

Benefits

• healthcare coverage
• annual incentive program
• retirement benefits
• broad range of other benefits

About the company

Metaphore Bio is a generative AI drug design company creating a new class of functional antibodies.