Senior Analog/Mixed-Signal Hardware Engineer, Single-Molecule Sensing Instrumentation

The role

You will design and develop complex multilayer PCBs and low-noise mixed-signal circuit designs for biological sensing platforms. This role involves leading the design of analog front ends, power management, and data acquisition systems from prototype through production.

What you will do

• Lead the design and development of complex, multilayer PCBs for advanced instrumentation systems.
• Architect low-noise, mixed-signal circuit designs including analog front ends, power management, data acquisition, and embedded processing systems.
• Collaborate with SW and HW engineers and external vendors for hardware-software integration.
• Develop and maintain documentation including schematics, layout files, validation reports, and specifications.
• Drive design reviews, design for manufacturability (DFM), and design for testability (DFT) best practices.
• Contribute to intellectual property generation and technical strategy discussions.

Required qualifications

• B.S., M.S., or Ph.D. in Electrical Engineering or a related field.
• 5+ years of industry experience in PCB design and hardware development.
• Demonstrated expertise in multilayer PCB design for low-noise analog and mixed-signal systems.
• Deep understanding of signal integrity, power integrity, grounding strategies, and EMI/EMC mitigation.
• Hands-on experience with board bring-up, debugging, and lab instrumentation (oscilloscopes, logic analyzers, spectrum analyzers).
• Experience taking products from prototype through manufacturing.

Nice to have

• Experience with low-noise electrophysiology, patch-clamp, or nanopore instrumentation.
• Experience with high-speed interfaces (e.g., USB, Ethernet, PCIe, DDR, SPI, I2C).
• Experience designing electronics for scientific instrumentation, medical devices, or life sciences platforms.
• Familiarity with FPGA-based systems and embedded processors.
• Experience with high-density interconnect (HDI) design and fine-pitch components.
• Knowledge of regulatory compliance standards (e.g., CE, FCC, IEC).
• Experience working in early-stage or startup environments.

Benefits

• Healthcare coverage
• Annual incentive program
• Retirement benefits
• Broad range of other benefits

About the company

Tilde Bio, Inc. (FL110) is a Flagship Pioneering company building a next-generation biological sensing platform. The company aims to create programmable biological measurement systems using nanopore biophysics and other disciplines.